p90 Autoantigen (KIAA1524) Mouse Monoclonal Antibody [Clone ID: 2G10]
CAT#: TA301640
Mouse Monoclonal Antibody against CIP2A (2G10)
Need it in bulk or conjugated?
Get a free quote
CNY 5,381.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
Specifications
Product Data | |
Clone Name | 2G10 |
Applications | FC, ICC/IF, IHC, WB |
Recommend Dilution | Knockdown Validated, Western Blot: 1:1000-1:2000, Immunocytochemistry/ Immunofluorescence: 1:40, Flow Cytometry: 1 ug per million cells, Immunohistochemistry: 1:100 - 1:200, Immunohistochemistry-Paraffin |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | A C-terminal portion of the human p90 protein. |
Formulation | Tris-glycine, 150mM NaCl and 0.05% sodium azide |
Concentration | lot specific |
Purification | protein G purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | KIAA1524 |
Database Link | |
Background | Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer. |
Synonyms | CIP2A; p90 |
Reference Data | |
Protein Families | Druggable Genome |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
其它p90 Autoantigen产品