BIRC5 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, ELISA, FC, ICC/IF, IHC, IP, Simple Western, WB
Recommend Dilution	Immunohistochemistry-Frozen, Flow Cytometry, ELISA, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Immunohistochemistry: 1:50-1:100, Immunocytochemistry/ Immunofluorescence: 1:50-1:250, Immunoprecipitation: 1:10-1:500, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:50-1:500, Simple Western: 1:25, Dual RNAscope ISH-IHC, Knockdown Validated
Reactivity	Human, Mouse, Rat, Feline, Dog
Host	Rabbit
Clonality	Polyclonal
Immunogen	Full-length recombinant human survivin.
Formulation	Tris-glycine with 150mM NaCl and 0.05% sodium azide
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	baculoviral IAP repeat containing 5
Database Link	NP_001159 Entrez Gene 11799 MouseEntrez Gene 64041 RatEntrez Gene 442936 DogEntrez Gene 332 Human UniProt ID O15392
Background	Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminal RING finger and are thought to block an evolutionary conserved step in apoptosis.
Synonyms	API4; EPR-1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Colorectal cancer, Pathways in cancer

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