p53 (TP53) Rabbit Polyclonal Antibody

CAT#: TA302000

Rabbit Polyclonal Antibody against TP53 (S15)



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CNY 6,160.00


货期*
5周

规格
    • 400 ul

Product images

经常一起买 (4)
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Recombinant protein of human tumor protein p53 (TP53), transcript variant 1, 20 µg
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Recombinant protein of human tumor protein p53 (TP53), transcript variant 1, 100 µg
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Specifications

Product Data
Applications IF, WB
Recommend Dilution WB: 1:1000, IF: 1:10~50
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen This p53 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from human p53.
Formulation Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Concentration lot specific
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 43653 Da
Gene Name tumor protein p53
Background Tumor protein p53, a nuclear protein, plays an essential role in the regulation of cell cycle, specifically in the transition from G0 to G1. It is found in very low levels in normal cells, however, in a variety of transformed cell lines, it is expressed in high amounts, and believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing DNA-binding, oligomerization and transcription activation domains. It is postulated to bind as a tetramer to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of the TP53 gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome.
Synonyms BCC7; LFS1; P53; TRP53
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways Amyotrophic lateral sclerosis (ALS), Apoptosis, Basal cell carcinoma, Bladder cancer, Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, Glioma, Huntington's disease, MAPK signaling pathway, Melanoma, Neurotrophin signaling pathway, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer, Thyroid cancer, Wnt signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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