FGFR4 Mouse Monoclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:2000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant FGFR4 fusion protein was used to produced this monoclonal antibody.
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	lot specific
Purification	This antibody is purified through a protein G column, followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	87954 Da
Gene Name	fibroblast growth factor receptor 4
Database Link	NP_002002 Entrez Gene 2264 Human UniProt ID P22455
Background	FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Synonyms	CD334; JTK2; TKF
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Endocytosis, MAPK signaling pathway, Regulation of actin cytoskeleton

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