NANOG Rabbit Polyclonal Antibody
CAT#: TA302153
Rabbit Polyclonal Antibody against NANOG (N-term)
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CNY 6,446.00
货期*
5周
规格
Cited in 1 publication. |
经常一起买 (2)
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Specifications
Product Data | |
Applications | FC, IF, IHC, WB |
Recommend Dilution | WB: 1:1000, IF: 1:10~50, IHC: 1:10~50, FC: 1:10~50 |
Reactivity | Human, Monkey |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | This NANOG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-49 amino acids from the N-terminal region of human NANOG. |
Formulation | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
Concentration | lot specific |
Purification | This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Predicted Protein Size | 34489 Da |
Gene Name | Nanog homeobox |
Database Link | |
Background | NANOG is a transcription regulator involved in inner cell mass and embryonic stem (ES) cell proliferation and self-renewal. It imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. This protein blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. NANOG acts as a transcriptional activator or repressor. It binds optimally to the DNA consensus sequence 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, this protein promotes cells to enter into S phase and proliferation. |
Synonyms | homeobox transcription factor Nanog; homeobox transcription factor Nanog-delta 48; Nanog homeobox |
Reference Data | |
Protein Families | Cancer stem cells, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Stem cell - Pluripotency |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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CHI3L1 results in poor outcome of ovarian cancer by promoting properties of stem-like cells
,Lin, HW;Chiang, YC;Sun, NY;Chen, YL;Chang, CF;Tai, YJ;Chen, CA;Cheng, WF;,
Endocr. Relat. Cancer
,PubMed ID 30121622
[NANOG]
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