G protein beta subunit like (MLST8) Rabbit Polyclonal Antibody

CAT#: TA302160

Rabbit Polyclonal Antibody against GBL (Center)



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CNY 6,160.00


货期*
5周

规格
    • 400 ul

Product images

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 1:1000, IHC: 1:50~100
Reactivity Human, Mouse, Rat, Bovine
Host Rabbit
Clonality Polyclonal
Immunogen This GBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-170 amino acids from the Central region of human GBL.
Formulation Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 35876 Da
Gene Name MTOR associated protein, LST8 homolog
Background GBL (G protein beta protein subunit-like) is a member of a signaling pathway that regulates mammalian cell growth in response to the presence of nutrients and growth factors. It binds to the kinase domain of TOR (Target of rapamycin, also known as mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with GBL and an additional regulatory protein RAPTOR, allowing TOR to control protein biosynthesis. The binding of GBL to TOR stimulates TOR's kinase activity towards downstream proteins such as RPS6K (ribosomal protein S6 kinase) and the translation factor 4E-BP1 which leads to increased protein translation and cell growth.
Synonyms GbetaL; GBL; LST8; POP3; WAT1
Reference Data
Protein Pathways mTOR signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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