CILP Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:128,000. WB: 0.1-0.3µg/ml.
Reactivity	Rat, Human, Mouse, Dog
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-NYRRTDHEDPRVK, from the internal region of the protein sequence according to NP_003604.2.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	136204 Da
Gene Name	cartilage intermediate layer protein
Database Link	NP_003604 Entrez Gene 214425 MouseEntrez Gene 315761 RatEntrez Gene 487603 DogEntrez Gene 8483 Human UniProt ID O75339
Background	Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase, however later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. One isoform of the protein, CILP-1, functions as an IGF-1 antagonist.
Synonyms	CILP-1; HsT18872
Reference Data
Protein Families	Druggable Genome, Phosphatase, Secreted Protein

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