MRP4 (ABCC4) Goat Polyclonal Antibody
CAT#: TA302970
Goat Polyclonal Antibody against ABCC4
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CNY 5,371.00
Cited in 8 publications. |
CNY 4,840.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | ELISA: 1:64,000. WB: 1-3µg/ml. IHC: 2-4µg/ml. |
Reactivity | Human, Rat, Mouse |
Host | Goat |
Clonality | Polyclonal |
Immunogen | Peptide with sequence CNGQPSTLTIFETAL, from the C Terminus of the protein sequence according to NP_005836.2. |
Formulation | Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. |
Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | ATP binding cassette subfamily C member 4 |
Database Link | |
Background | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq] |
Synonyms | MOAT-B; MOATB; MRP4 |
Reference Data | |
Protein Families | Druggable Genome, Ion Channels: Other, Transmembrane |
Protein Pathways | ABC transporters |
Citations (8)
The use of this Antibodies has been cited in the following citations: |
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The Efflux Mechanism of Fraxetin-O-Glucuronides in UGT1A9-Transfected HeLa Cells: Identification of Multidrug Resistance-Associated Proteins 3 and 4 (MRP3/4) as the Important Contributors
,Qin, Z;Zhang, B;Yang, J;Li, S;Xu, J;Yao, Z;Zhang, X;Gonzalez, FJ;Yao, X;,
Front Pharmacol
,PubMed ID 31133859
[ABCC4]
|
Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression
,Orlando, UD;Castillo, AF;Medrano, MAR;Solano, AR;Maloberti, PM;Podesta, EJ;,
Biochem. Pharmacol.
,PubMed ID 30414939
[ABCC4]
|
Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin
,Liu, T;Zhang, X;Zhang, Y;Hou, J;Fang, D;Sun, H;Li, Q;Xie, S;,
Eur J Pharm Sci
,PubMed ID 30176366
[ABCC4]
|
Efflux excretion of bisdemethoxycurcumin-O-glucuronide in UGT1A1-overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 (MRP1) as the glucuronide transporters
,Yang, J;Zhang, B;Qin, Z;Li, S;Xu, J;Yao, Z;Zhang, X;Gonzalez, FJ;Yao, X;,
Biofactors
,PubMed ID 30334318
[ABCC4]
|
The roles of breast cancer resistance protein (BCRP/ABCG2) and multidrug resistance-associated proteins (MRPs/ABCCs) in the excretion of cycloicaritin-3-O-glucoronide in UGT1A1-overexpressing HeLa cells
,Li, S;Xu, J;Yao, Z;Hu, L;Qin, Z;Gao, H;Krausz, KW;Gonzalez, FJ;Yao, X;,
Chem. Biol. Interact.
,PubMed ID 30237061
[ABCC4]
|
Efflux transport of chrysin and apigenin sulfates in HEK293 cells overexpressing SULT1A3: The role of multidrug resistance-associated protein 4 (MRP4/ABCC4)
,Li, W;Sun, H;Zhang, X;Wang, H;Wu, B;,
Biochem. Pharmacol.
,PubMed ID 26291395
[ABCC4]
|
Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay
,Zhang, X;Dong, D;Wang, H;Ma, Z;Wang, Y;Wu, B;,
Mol. Pharm.
,PubMed ID 25741749
[ABCC4]
[Human; WB] |
Characterization of Chrysin Glucuronidation in UGT1A1-Overexpressing HeLa Cells: Elucidating the Transporters Responsible for Efflux of Glucuronide
,Quan, E;Wang, H;Dong, D;Zhang, X;Wu, B;,
Drug Metab. Dispos.
,PubMed ID 25595598
[ABCC4]
[Human; WB] |
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