HGS Goat Polyclonal Antibody

CAT#: TA303100

Goat Polyclonal Antibody against HGS



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CNY 5,371.00


货期*
5周

规格
    • 100 ug

Product images

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Recombinant protein of human hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), 20 µg
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Recombinant protein of human hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), 100 µg
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Specifications

Product Data
Applications IHC
Recommend Dilution ELISA: 1:32,000. WB: 1-2µg/ml.
Reactivity Human, Mouse, Rat, Dog
Host Goat
Clonality Polyclonal
Immunogen Peptide with sequence C-NRNYWEKKQEEARK, from the internal region of the protein sequence according to NP_004703.1.
Formulation Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration lot specific
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name hepatocyte growth factor-regulated tyrosine kinase substrate
Background Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex
Synonyms HRS
Reference Data
Protein Families Druggable Genome
Protein Pathways Endocytosis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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