OTUB1 Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.03-0.1ug/ml.
Reactivity	Mouse, Human, Rat, Cow
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-YKEYAEDDNIYQQK, from the internal region of the protein sequence according to NP_060140.2.
Formulation	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Concentration	lot specific
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20C. Minimize freezing and thawing.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	OTU deubiquitinase, ubiquitin aldehyde binding 1
Database Link	NP_060140 Entrez Gene 107260 MouseEntrez Gene 293705 RatEntrez Gene 55611 Human UniProt ID Q96FW1
Background	The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.
Synonyms	HSPC263; OTB1; OTU1
Reference Data
Protein Families	Protease

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