DcR1 (TNFRSF10C) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC, IF, WB
Recommend Dilution	DcR1 antibody can be used for detection of DcR1 by Western blot 0.5 µg/mL. An approximate 65 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL. Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DcR1 antibody was raised against a peptide corresponding to amino acids in a extracellular domain (ED) of human DcR1 precursor.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	DcR1 Antibody is DEAE purified.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tumor necrosis factor receptor superfamily member 10c
Database Link	AF012536 Entrez Gene 8794 Human UniProt ID O14798
Background	Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts were expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
Synonyms	CD263; DCR1; DCR1-TNFR; LIT; TRAIL-R3; TRAILR3; TRID
Reference Data

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