Nephrin (NPHS1) Rabbit Polyclonal Antibody
CNY 5,808.00
Cited in 2 publications. |
CNY 4,840.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, IHC, WB |
Recommend Dilution | WB: 1 ug/mL, ICC: 1 ug/mL, IF: 10 ug/mL |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Nephrin antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human Nephrin. The immunogen is located within the last 50 amino acids of Nephrin. |
Formulation | PBS containing 0.02% sodium azide. |
Purification | Affinity chromatography purified via peptide column |
Conjugation | Unconjugated |
Storage Condition | Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures. |
Gene Name | NPHS1 nephrin |
Database Link | |
Background | Nephrin is strongly expressed in renal glomeruli and is a member of the immunoglobulin family of cell adhesion molecules. Mutations in the Nephrin gene result in congenital nephrotic syndrome, an autosomal-recessive disorder characterized by massive proteinuria in utero and nephrosis at birth. Renal glomeruli allow normal kidneys to filter plasma so that it is very pure. Nephrin is expressed in the podocyte slit-diaphragm of the renal glomeruli in a manner that suggests that Nephrin molecules homodimerize in an anti-parallel fashion similar to cadherin interactions in adherens junctions. Thus, Nephrin may constitute the entire extracellular structure of the slit-diaphragm. Despite its predicted molecular weight, Nephrin often migrates at a lower than expected size in SDS-PAGE. |
Synonyms | CNF; nephrin; NPHN |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Citations (2)
The use of this Antibodies has been cited in the following citations: |
---|
A PAI-1 mutant retards diabetic nephropathy in db/db mice through protecting podocytes
,Zhang, J;Gu, C;Lawrence, DA;Cheung, AK;Huang, Y;,
Exp. Physiol., Jan 2014.
,PubMed ID 24443353
[NPHS1]
[Mouse; WB] |
Targeting reduction of proteinuria in glomerulonephritis: Maximizing the antifibrotic effect of valsartan by protecting podocytes
,Chunyan Gu, Guangyu Zhou, Nancy A Noble, Wayne A Border, Alfred K Cheung, and Yufeng Huang,
Journal of Renin-Angiotensin-Aldosterone System, Dec 2012; 10.1177/1470320312466127.
,PubMed ID 23223090
[NPHS1]
|
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