Diablo Rabbit Polyclonal Antibody

CAT#: TA306067

Rabbit Polyclonal Smac Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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Transient overexpression lysate of diablo homolog (Drosophila) (DIABLO), nuclear gene encoding mitochondrial protein, transcript variant 1
    • 100 ug

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Specifications

Product Data
Applications ELISA, IF, IHC, IP, WB
Recommend Dilution WB: 1 µg/mL; IF: 10 µg/mL; IHC: 2 µg/mL.
Antibody validated: Western Blot in mouse and rat samples; Immunofluorescence and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen Smac antibody was raised against a peptide corresponding to amino acids 222 to 237 of murine Smac/DIABLO.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Smac Antibody is DEAE purified.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name diablo, IAP-binding mitochondrial protein
Background The inhibitor of apoptosis proteins (IAPs) regulate programmed cell death by inhibiting members of the caspase family of enzymes. A novel mammalian protein that binds to IAPs and neutralizes the inhibitory effect of IAPs on caspases was recently identified and designated Smac/DIABLO (1,2). Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and activates cytochrome c/Apaf-1/capase-9 pathway. Analysis of the structural basis of Smac/DIABLO reveals that the N-terminal amino acids are required for binding of Smac/DIABLO to IAPs and activation of caspases (3-6). Smac/DIABLO is expressed in a variety of human and mouse tissues (1,2).
Synonyms DFNA64; SMAC
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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