CARD10 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 5 - 10 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	CARD10 antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of human CARD10.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	immunoaffinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase recruitment domain family member 10
Database Link	AAK26165 Entrez Gene 29775 Human UniProt ID Q9BWT7
Background	Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD-containing protein was recently identified and designated CARD10 (1). This protein belongs to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules (2). CARD 10 interacts with Bcl-10, a Bcl protein that promotes apoptosis, caspase-9 maturation and activation of NF-kappaB (1,3). CARD 10 and the related protein CARMA1 also associate with NEMO, the regulatory subunit of the IkappaK complex (4), demonstrating its importance in the regulation of NF-kappaB transcription factor activation.
Synonyms	BIMP1; CARMA3
Reference Data

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