NALP2 (NLRP2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NALP2 antibody was raised against a peptide corresponding to 12 amino acids near the carboxy-terminus of human NALP2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Immunoaffinity chromatography purified IgG
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	NLR family, pyrin domain containing 2
Database Link	NP_060322 Entrez Gene 232827 MouseEntrez Gene 684545 RatEntrez Gene 55655 Human UniProt ID Q9NX02
Background	NALP2 belongs to a family of cytoplasmic proteins that have been implicated in cell responses to apoptotic and inflammatory stimuli (1). Unlike the prototypical NALP protein NALP1, NALP2 only contains a NACHT domain, leucine rich repeat (LRR), and pyrin-containing domain (PYD) (2). This protein interacts with the adapter protein ASC in addition to CARD8 and caspase-1 to form an inflammasome with high proIL-1Β-processing activity and is thought to function as a modulator of NF-ΚB and procaspase-1 activation in macrophages (2,3). It has also been suggested that NALP2, in addition to other NALP family members, can act as innate sensors of pathogens in a manner similar to the toll-like receptors (TLRs) (4). At least two alternatively spliced transcript variants encoding distinct isoforms have been found for NALP2.
Synonyms	CLR19.9; NALP2; NBS1; PAN1; PYPAF2
Reference Data

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