BCL2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC, WB
Recommend Dilution	WB: 1-4µg/mL; ICC: 2 µg/mL. Antibody validated: Western Blot in human and mouse samples; Immunocytochemistry in mouse samples. All other applications and species not yet tested.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Bcl-2 antibody was raised against a peptide corresponding to 14 amino acids near the middle of human Bcl-2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Bcl-2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	B-cell CLL/lymphoma 2
Database Link	AAH27258 Entrez Gene 596 Human UniProt ID P10415
Background	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). Bcl-2 is the founding member of a family of over 20 proteins that are critical regulators of apoptosis (reviewed in 2 and 3). These can be divided into two classes: those that inhibit apoptosis and those that promote cell death. Bcl-2 is an inner mitochondrial membrane protein that inhibits apoptosis (4). It is thought to act by interacting with pro-apoptotic Bcl-2 family members such as Bak and Bad (5 for review). Overexpression of Bcl-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer (4,6).
Synonyms	Bcl-2; PPP1R50
Reference Data

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