Bak (BAK1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, ICC, WB
Recommend Dilution	Bak antibody can be used for detection of Bak by Western blot at 1 to 2 µg/mL. Antibody can also be used for immunocytochemistry starting at 2 µg/mL. Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Bak antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Bak Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BCL2 antagonist/killer 1
Database Link	NP_001179 Entrez Gene 12018 MouseEntrez Gene 578 Human UniProt ID Q16611
Background	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria (4,5). It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability (6,7).
Synonyms	BAK; BAK-LIKE; BCL2L7; CDN1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transmembrane

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