Caspase 5 (CASP5) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 - 2 ug/mL, ICC: 2 ug/mL, IF: 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Caspase-5 antibody was raised against a 14 amino acid peptide from the center of human Caspase-5.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	caspase 5
Database Link	NP_001129581 Entrez Gene 838 Human UniProt ID P51878
Background	Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1). Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1beta and IL-18 (2,3). Caspase-5 can interact with caspase-1; both are constituents of the NALP1 inflammasome, a complex that can trigger the cleavage of pro-IL-1beta (4). Expression of caspase-5 can be regulated by lipopolysaccharide (LPS) and IFN-ϒ (5).
Synonyms	ICE(rel)III; ICEREL-III; ICH-3
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	NOD-like receptor signaling pathway

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