RSK1 p90 (RPS6KA1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 2.5 - 10 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	RPS6K1 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human RPS6K1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ribosomal protein S6 kinase A1
Database Link	AAC82497 Entrez Gene 6195 Human UniProt ID Q15418
Background	Ribosomal protein S6 kinase 1 (RPS6K1) is the best characterized effector of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (1,2). Nutrients and growth factors stimulate a complex including TOR, raptor (regulatory associated protein of TOR), and G?L to phosphorylate RPS6K1 and the eukaryotic initiation factor 4E binding protein (4EBP1), leading to increased protein synthesis and cell growth (3). RPS6K1 is thought to desensitize tissues to insulin as mice deficient in RPS6K1 have been shown to be hypersensitive to insulin and impervious to obesity-induced insulin resistance seen in wild type obese mice (4).
Synonyms	HU-1; MAPKAPK1A; p90Rsk; RSK; RSK1
Reference Data

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