p75 NGF Receptor (NGFR) Rabbit Polyclonal Antibody

CAT#: TA306246

Rabbit Polyclonal NGFR Antibody



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CNY 5,808.00


货期*
4周

规格
    • 100 ug

Product images

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Specifications

Product Data
Applications ELISA, ICC, IF, WB
Recommend Dilution NGFR antibody can be used for the detection of NGFR by Western blot at 1 µg/mL. Antibody can also be used for immunocytochemistry starting at 10 µg/mL. For immunofluorescence start at 20 µg/mL.
Antibody validated: Western Blot in human samples, Immunocytochemistry in mouse samples and Immunofluorescence in human samples. . All other applications and species not yet tested.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen NGFR antibody was raised against purified recombinant human NGFR.
Formulation PBS containing 0.02% sodium azide.
Purification NGFR Antibody is Protein A purified.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name nerve growth factor receptor
Background The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kappaB and various mitogen-activated protein kinases (reviewed in 1). Nerve growth factor receptor (NGFR) was one of the earliest characterized members of this family (2). Also known as the low-affinity receptor p75NTR, this receptor is involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination (reviewed in 3). Its ligands include NGF, brain-derived neurotrophic factor (BDNF), NT3, and NT4 (4). NGFR can also associate with other NGF receptors such as Trk through the cytosolic and transmembrane domains and thus can function as a co-receptor that refines Trk affinity and specificity for neurotrophins (5). Finally, upon binding of various neurotrophins, NGFR associates with tumor necrosis factor receptor-6 (TRAF6), suggesting that it can potentially function as a signal transducer for NGF signals through NGFR (6).
Synonyms CD271; Gp80-LNGFR; p75(NTR); p75NTR; TNFRSF16
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Neurotrophin signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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