SP110 Rabbit Polyclonal Antibody

CAT#: TA306505

Rabbit Polyclonal IPR1 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

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经常一起买 (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Transient overexpression lysate of SP110 nuclear body protein (SP110), transcript variant d
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 0.5 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen IPR1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of the human IPR1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name SP110 nuclear body protein
Background Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.
Synonyms IFI41; IFI75; IPR1; VODI
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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