POFUT1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	POFUT1 antibody was raised against a 16 amino acid peptide from near the amino terminus of human POFUT1.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	protein O-fucosyltransferase 1
Database Link	NP_056167 Entrez Gene 140484 MouseEntrez Gene 23509 Human UniProt ID Q9H488
Background	POFUT1, an endoplasmic reticulum-residing member of the glycosyltransferase O-Fuc family, adds O-fucose through an O-glycosidic linkage to conserved serine or threonines in epidermal growth factor-like repeats of several cell surface and secreted proteins. Unlike its homolog POFUT2, POFUT1 can also catalyze the transfer of fucose to thrombospondin type 1 repeats. Many of the substrates of POFUT1 are involved in ligand-induced receptor signaling. One such protein is Notch; mouse ES cells lacking POFUT have normal levels of Notch receptors at the cell surface, but these receptors do not bind Notch ligands or exhibit Notch signaling. At least two isoforms of POFUT1 are known to exist. This antibody is predicted to not cross-react with POFUT2.
Synonyms	DDD2; FUT12; O-Fuc-T; O-FucT-1; O-FUT; OFUCT1
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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