Activin A Receptor Type IB (ACVR1B) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	ACVR1B antibody was raised against a 14 amino acid peptide near the carboxy terminus of the human ACVR1B.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	activin A receptor type 1B
Database Link	NP_064732 Entrez Gene 91 Human UniProt ID P36896
Background	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions. At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.
Synonyms	ACTRI; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
Reference Data

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