SPRED2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1 - 2 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Spred2 antibody was raised against a 13 amino acid peptide near the center of the human Spred2.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sprouty related EVH1 domain containing 2
Database Link	NP_861449 Entrez Gene 200734 Human UniProt ID Q7Z698
Background	Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist. This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.
Synonyms	Spred-2
Reference Data

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