DCAMKL1 (DCLK1) Rabbit Polyclonal Antibody

CAT#: TA306935

Rabbit Polyclonal DCLK1 Antibody



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CNY 5,808.00


货期*
5周

规格
    • 100 ug

Product images

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Specifications

Product Data
Applications IF, IHC, WB
Recommend Dilution WB: 0.5 - 1 ug/mL, ICC: 2.5 ug/mL
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen DCLK1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human DCLK1. The immunogen is located within the last 50 amino acids of DCLK1.
Formulation PBS containing 0.02% sodium azide.
Concentration 1ug/ul
Purification Affinity chromatography purified via peptide column
Conjugation Unconjugated
Storage Condition Antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Gene Name doublecortin like kinase 1
Background DCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.
Synonyms CL1; CLICK1; DCAMKL1; DCDC3A; DCLK
Reference Data
Protein Families Druggable Genome, Protein Kinase
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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