Ataxin 3 (ATXN3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	IHC:1:100-1:1000; WB:1:500-1:10000
Reactivity	Human, Mouse, Pig, Rat, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 1 and 245 of Ataxin 3 (Uniprot ID#P54252)
Formulation	1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	42 kDa
Gene Name	ataxin 3
Database Link	NP_001121169 Entrez Gene 60331 RatEntrez Gene 110616 MouseEntrez Gene 4287 Human UniProt ID P54252
Background	Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]
Synonyms	AT3; ATX3; JOS; MJD; MJD1; SCA3
Note	Seq homology of immunogen across species: Pig (99%), Rat (96%), Bovine (98%)
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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