AP2M1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Mouse, Rat, Bovine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment contain a sequence corresponding to a region within amino acids 1 and 150 of AP2M1 (Uniprot ID#Q96CW1)
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50 kDa
Gene Name	adaptor related protein complex 2 mu 1 subunit
Database Link	NP_001020376 Entrez Gene 11773 MouseEntrez Gene 116563 RatEntrez Gene 1173 Human UniProt ID Q96CW1
Background	This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms	AP50; CLAPM1; mu2
Note	Seq homology of immunogen across species: Mouse (100%), Rat (100%), Bovine (100%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Endocytosis, Huntington's disease

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