SDHB Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	ICC/IF:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Rat, Pig, Bovine, Rhesus Monkey
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region within amino acids 221 and 280 of SDHB (Uniprot ID#P21912)
Formulation	1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	32 kDa
Gene Name	succinate dehydrogenase complex iron sulfur subunit B
Database Link	NP_002991 Entrez Gene 298596 RatEntrez Gene 6390 Human UniProt ID P21912
Background	Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq]
Synonyms	CWS2; IP; PGL4; SDH; SDH1; SDH2; SDHIP
Note	Seq homology of immunogen across species: Rat (87%), Pig (100%), Rhesus Monkey (100%), Bovine (89%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

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