Thymidylate Synthase (TYMS) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB:1:500-1:3000
Reactivity	Human, Mouse, Monkey, Pig, Rat, Zebrafish, X. tropicalis
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant fragment corresponding to a region within amino acids 122 and 313 of Thymidylate synthetase (Uniprot ID#P04818)
Formulation	1XPBS, 1% BSA, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	36 kDa
Gene Name	thymidylate synthetase
Database Link	NP_001062 Entrez Gene 22171 MouseEntrez Gene 29261 RatEntrez Gene 697580 MonkeyEntrez Gene 7298 Human UniProt ID P04818
Background	Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]
Synonyms	HST422; TMS; TS
Note	Seq homology of immunogen across species: Mouse (94%), Monkey (98%), Pig (96%), Rat (95%), Zebrafish (87%), Xenopus tropicalis (85%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolic pathways, One carbon pool by folate, Pyrimidine metabolism

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