H2A.Z (H2AFZ) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity	Human, Rat, Zebrafish, Xenopus, Pig, Chicken, Sheep, Bovine, Rhesus Monkey, X. tropicalis, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region within amino acids 1 and 45 of Histone H2A.Z
Formulation	0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration	lot specific
Purification	Purified by antigen-affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	14 kDa
Gene Name	H2A histone family member Z
Database Link	NP_002097 Entrez Gene 51788 MouseEntrez Gene 58940 RatEntrez Gene 3015 Human UniProt ID P0C0S5
Background	Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq]
Synonyms	H2A; H2A.z; H2A.Z-1; H2AZ; z
Note	Seq homology of immunogen across species: Mouse (100%), Rat (100%), Zebrafish (100%), Xenopus laevis (92%), Xenopus Tropicalis (92%), Pig (100%), Chicken (93%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Systemic lupus erythematosus

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