Syntaxin 1a (STX1A) Mouse Monoclonal Antibody [Clone ID: SP8]

Specifications

Product Data
Clone Name	SP8
Applications	WB
Recommend Dilution	WB: 1:1000, IHC: 1:100
Reactivity	Human, Porcine, Hamster, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synaptic immunoprecipitate (crude) from human brain
Formulation	100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	36 kDa
Gene Name	syntaxin 1A
Database Link	NP_004594 Entrez Gene 116470 RatEntrez Gene 6804 Human UniProt ID Q16623
Background	This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms	HPC-1; P35-1; STX1; SYN1A
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	SNARE interactions in vesicular transport

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