App Goat Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 0.03-1ug/ml
Reactivity	Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence DAEFGHDSGFEVRHQK-C, from the N Terminus of the protein sequence according to NP_001185752.1; NP_031497.2; NP_001185753.1; NP_001185754.1; NP_001185755.1.
Formulation	Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Purification	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	amyloid beta (A4) precursor protein
Database Link	NP_031497 Entrez Gene 54226 RatEntrez Gene 11820 Mouse UniProt ID P12023
Background	This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]
Synonyms	A4; AAA; ABPP; AD1; APPI; CTFgamma; CVAP; OTTHUMP00000096096; PN-II; PN2; PreA4
Reference Data

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