TP53BP2 Rabbit Polyclonal Antibody
CAT#: TA319332
Rabbit polyclonal anti-ASPP2 antibody
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CNY 8,025.00
CNY 3,080.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | WB |
Recommend Dilution | ELISA: 1:2,500 - 1:10,000, WB: 1:500 - 1:3,000, IHC: User Optimized |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal sequence of human ASPP2. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | tumor protein p53 binding protein 2 |
Database Link | |
Synonyms | 53BP2; ASPP2; BBP; P53BP2; PPP1R13A |
Note | ASPP (ankyrin-repeat-, SH3-domain- proline-rich-region protein) proteins (ASPP1, ASPP2 and iASPP) represent a new family of p53 binding proteins. ASPP1 and ASPP2 bind and enhance p53-mediated apoptosis. In contrast, iASPP functionally inactivates p53. ASPPs may also regulate p63- and p73-mediated apoptosis. Both ASPP1 and 2 directly interact with p53 and specifically enhance the apoptotic function of p53 by stimulating its DNA binding and transactivation function on promoters of pro-apoptotic genes, such as Bax and PIG-3. Not all cell cycle arrest genes are affected, such as p21. Interestingly, expression of ASPP is frequently down-regulated in human breast carcinomas expressing wild-type p53 but not mutant p53. Therefore, ASPP might regulate the tumor suppression function of p53 in vivo. |
Reference Data | |
Protein Families | Druggable Genome |
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