Sprouty 2 (SPRY2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	ELISA: User Optimized, WB: 1:500-1:5,000, IF: User Optimized
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Anti-Sprouty-2 affinity purified antibody was purified from monospecific rabbit antiserum prepared via repeated immunizations with human sprouty-2 peptide.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	sprouty RTK signaling antagonist 2
Database Link	NP_005833 Entrez Gene 10253 Human UniProt ID O43597
Synonyms	hSPRY2; IGAN3
Note	Sprouty was originally identified as an inhibitor of Drosophila epidermal growth factor (EGF) and fibroblast growth factor (FGF) receptor signaling during tracheal development. Four isoforms of mammalian sprouty are known (Spry1-Spry4). The role of the mammalian analogs has not been clearly elucidated although it is believed that human Sprouty-2 (hSpry2) may be an inhibitor of cellular migration and proliferation. Spry2 and Spry4 show considerable sequence homology between human and mouse at the C-terminus of the protein. Significant sequence divergence occurs at the N-terminus. Spry2 appears to be abundant in brain, lung and heart tissue, with lesser amounts found in kidney and skeletal muscle.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Jak-STAT signaling pathway

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