ZIC2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	ELISA: 1:10,000 - 1:50,000, WB: 1:500 - 1:2,000
Reactivity	Human, Chimpanzee, Mouse, Rat, Dog
Host	Rabbit
Clonality	Polyclonal
Immunogen	This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding amino acids 189-206 of Mouse ZIC-2.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Zic family member 2
Database Link	NP_009060 Entrez Gene 22772 MouseEntrez Gene 361096 RatEntrez Gene 485533 DogEntrez Gene 7546 Human UniProt ID O95409
Synonyms	HPE5
Note	ZIC2 (also known as zinc finger protein of the cerebellum 2, HPE5, Zic family member 2 and odd-paired Drosophila homolog) is a nuclear protein that functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. In mouse, knockout of Zic1 leads to aplasia of cerebellum and skeletal abnormalities. Mutation in Zic2 and Zic3 in mouse and/or human cause holoprosencephaly and heterotaxis, respectively. Holoprosencephaly is the most common structural anomaly of the human brain.
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Hedgehog signaling pathway

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