Ahsa1 Rat Monoclonal Antibody [Clone ID: 25F2.D9]
CNY 8,303.00
CNY 300.00
CNY 1,430.00
CNY 2,900.00
Specifications
Product Data | |
Clone Name | 25F2.D9 |
Applications | IHC, WB |
Recommend Dilution | ELISA: 1:20,000, WB: 1:1,000, IHC: 5-10 ug/mL |
Reactivity | Mouse, Human, Chimpanzee |
Host | Rat |
Clonality | Monoclonal |
Immunogen | This Protein G purified monoclonal antibody was produced in rats by repeated immunizations with full length recombinant mouse AHA1 protein followed by hybridoma development. |
Formulation | 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
Concentration | lot specific |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | AHA1, activator of heat shock protein ATPase 1 |
Database Link | |
Synonyms | AHA1; C14orf3; p38 |
Note | Activator of Hsp90 ATPase (AHA1) stimulates the inherent ATPase cycle of Hsp90, which is essential for its chaperone activity in vivo. The activation and/or stability of many of the key regulatory and signaling proteins of the eukaryotic cell depend on their interaction with the Hsp90 molecular chaperone. Hsp90 is assisted and regulated by co-chaperones that participate in an ordered series both to assist client-protein recruitment or release and to modulate progress through the ATPase coupled chaperone cycle. Structural analysis and mutagenesis show that binding of the N-terminal domain of AHA1 to Hsp90 promotes a conformational switch in the middle-segment catalytic loop (aa 370–390) of Hsp90 that exposes the catalytic Arg380 and enables its interaction with ATP in the N-terminal nucleotide-binding domain of the chaperone. Recent studies show that AHA1 modulates Hsp90-dependent stability of the folding of the cystic fibrosis transmembrane conductance regulator (CFTR) in the endoplasmic reticulum (ER). Down-regulation of AHA1 rescues misfolding of CFTR in cystic fibrosis. |
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