PDCD4 Mouse Monoclonal Antibody [Clone ID: 9G6]

Specifications

Product Data
Clone Name	9G6
Applications	IHC, WB
Recommend Dilution	ELISA: 1:20,000 - 1:100,000, WB: 1:2,000 - 1:10,000, IHC: 1:1,000 - 1:5,000
Reactivity	Human, Mouse, Rat, Xenopus
Modifications	Phospho-specific
Host	Mouse
Clonality	Monoclonal
Immunogen	This monoclonal antibody was produced by repeated immunizations with a synthetic peptide corresponding to residues surrounding Ser457 of the human Pdcd4 protein.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	programmed cell death 4 (neoplastic transformation inhibitor)
Database Link	NP_663314 Entrez Gene 18569 MouseEntrez Gene 64031 RatEntrez Gene 27250 Human UniProt ID Q53EL6
Synonyms	H731
Note	Programmed cell death 4 (Pdcd4) is a novel tumor supressor. Pdcd4 directly inhibits the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex. Pdcd4 also suppresses the transactivation of activator protein-1 (AP-1)-responsive promoters by c-Jun. Pdcd4 contains two Akt phosphoryl-ation sites, one at Ser67 and the other at Ser457. The phosphorylation of Pdcd4 by Akt causes nuclear translocation of Pdcd4 and a significant decrease in the ability of Pdcd4 to interfere with the transactivation of AP-1-responsive promoters by c-Jun.
Reference Data
Protein Families	Druggable Genome

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