Il17a Rat Monoclonal Antibody [Clone ID: 20B4.G10.F5]

Specifications

Product Data
Clone Name	20B4.G10.F5
Applications	FC, WB
Recommend Dilution	ELISA: 1:10,000, WB: 1:1000
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	This Protein A purified monoclonal antibody was produced in rats by repeated immunizations with full length recombinant mouse IL-17A protein (produced in E.coli) followed by hybridoma development.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 17A
Database Link	NP_034682 Entrez Gene 16171 Mouse UniProt ID Q62386
Synonyms	CTLA-8; CTLA8; IL-17; IL-17A; IL17
Note	Mouse Interleukin-17A (IL-17A), also known as CTLA-8, is a proinflammatory cytokine member of a six-species family of proteins (IL-17A-17F). Mouse IL-17A protein is a homodimer consisting of two 134 amino acids peptides. IL-17A is secreted mainly by activated CD4+ and CD8+ T lymphocytes and acts through its receptor, IL-17R, to induce the expression of many mediators of inflammation, most strikingly, those that are involved in the proliferation, maturation and chemotaxis of neutrophils. Elevated levels of IL-17A have been associated with several conditions, including rheumatoid arthritis, airway inflammation, allograft rejection, inflammatory bowel disease, psoriasis, cancer and multiple sclerosis. There is 58% identity between the amino acid sequence of human and mouse IL-17A. Anti-IL-17A antibody is ideal for investigators involved in Immunology research.
Reference Data

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