p57 Kip2 (CDKN1C) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	CDKN1C antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CDKN1C.
Formulation	CDKN1C Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CDKN1C Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	35 kDa
Gene Name	cyclin-dependent kinase inhibitor 1C
Database Link	NP_000067 Entrez Gene 1028 Human UniProt ID P49918
Background	CDKN1C Antibody: The cyclin-dependent kinase inhibitor 1C (CDKN1C), also known as p57KIP2, is a tight-binding, strong inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome, a cancer-predisposing syndrome, suggesting that this gene is a tumor suppressor candidate. CDKN1C is widely expressed during organogenesis with its expression declining after maturity. It is part of the CIP/KIP family of cyclin-dependent inhibitors (CKIs) which also includes CDKN1A and CDKN1B.
Synonyms	BWCR; BWS; KIP2; p57; p57Kip2; WBS
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Cell cycle

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