DYRK1A Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 10 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	DYRK1A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human DYRK1A. The immunogen is located within the last 50 amino acids of DYRK1A.
Formulation	DYRK1A Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	DYRK1A Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	dual specificity tyrosine phosphorylation regulated kinase 1A
Database Link	NP_001387 Entrez Gene 13548 MouseEntrez Gene 25255 RatEntrez Gene 1859 Human UniProt ID Q13627
Background	DYRK1A Antibody: DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family and is thought to be involved in neuronal differentiation, neurodegenerative diseases, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. DYRK1A phosphorylates several transcription factors such as p53, leading to inhibition of embryonic neuronal cell proliferation. DYRK1A associates with multiple proteins, including SPRED1 and SPRED2; this association appears to inhibit the phosphorylation activity of DYRK1A. Recent evidence also suggests that DYRK1A may be involved in the replication of HIV-1.
Synonyms	DYRK; DYRK1; HP86; MNB; MNBH; MRD7
Reference Data
Protein Families	Druggable Genome, Protein Kinase

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