KAL1 (ANOS1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Anosmin antibody was raised against an 18 amino acid synthetic peptide near the center of human Anosmin.
Formulation	Anosmin Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Anosmin Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	anosmin 1
Database Link	NP_000207 Entrez Gene 3730 Human UniProt ID P23352
Background	Anosmin Antibody: Mutations in Anosmin-1, an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
Synonyms	ADMLX; HH1; HHA; KAL; KAL1; KALIG-1; KMS; WFDC19
Reference Data

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