FOXO4 Rabbit Polyclonal Antibody
CNY 5,808.00
货期*
5周
规格
经常一起买 (1)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Applications | IF, WB |
Recommend Dilution | WB: 0.5 - 1 ug/mL, ICC: 10 ug/mL, IF: 20 ug/mL |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | FOXO4 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FOXO4. |
Formulation | FOXO4 Antibody is supplied in PBS containing 0.02% sodium azide. |
Concentration | 1ug/ul |
Purification | FOXO4 Antibody is affinity chromatography purified via peptide column. |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | forkhead box O4 |
Database Link | |
Background | FOXO4 Antibody: FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity. |
Synonyms | AFX; AFX1; MLLT7 |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...