ABCA7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 5 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	ABCA7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ABCA7.
Formulation	ABCA7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	ABCA7 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ATP binding cassette subfamily A member 7
Database Link	NP_061985 Entrez Gene 10347 Human UniProt ID Q8IZY2
Background	ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.
Synonyms	ABCA-SSN; ABCX; AD9
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	ABC transporters

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