Epac1 (RAPGEF3) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	EPAC1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human EPAC1.
Formulation	EPAC1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	EPAC1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	Rap guanine nucleotide exchange factor 3
Database Link	NP_001092001 Entrez Gene 59326 RatEntrez Gene 223864 MouseEntrez Gene 10411 Human UniProt ID O95398
Background	EPAC1 Antibody: EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.
Synonyms	bcm910; CAMP-GEFI; EPAC; EPAC1; HSU79275
Reference Data
Protein Pathways	Leukocyte transendothelial migration, Long-term potentiation

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