VASH1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	VASH1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human VASH1.
Formulation	VASH1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	VASH1 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	vasohibin 1
Database Link	NP_055724 Entrez Gene 238328 MouseEntrez Gene 503052 RatEntrez Gene 22846 Human UniProt ID Q7L8A9
Background	VASH1 Antibody: VASH1 was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. VASH1 mRNA is expressed brain, heart, kidney and placenta in the adult, with robust expression in various organs during embryonic development. VASH1 expression in tumor cells and tumor vasculature is silenced by methylation by increased expression of Zeste homolog 2 (EZH2). The increase of EZH2 expression is induced by VEGF stimulation, leading to poor clinical prognosis. Recombinant adenovirus expressing VASH prevented tumor angiogenesis and inhibited tumor growth, suggesting that it may be a potentially valuable antitumor therapy in the clinic.
Synonyms	KIAA1036
Reference Data
Protein Families	Secreted Protein

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