KDM6B Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 ug/mL, IF: 5 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	JMJD3 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human JMJD3.
Formulation	JMJD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	JMJD3 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	lysine demethylase 6B
Database Link	NP_001073893 Entrez Gene 216850 MouseEntrez Gene 363630 RatEntrez Gene 23135 Human UniProt ID O15054
Background	JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.
Synonyms	JMJD3
Reference Data

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