RASD2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	TEM2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of the human TEM2.
Formulation	TEM2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	TEM2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	RASD family member 2
Database Link	NP_055125 Entrez Gene 75141 MouseEntrez Gene 171099 RatEntrez Gene 23551 Human UniProt ID Q96D21
Background	TEM2 Antibody: Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.
Synonyms	MGC:4834; Rhes; TEM2
Reference Data
Protein Families	Druggable Genome

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