CHD7 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	CHD7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human CHD7.
Formulation	CHD7 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	CHD7 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	chromodomain helicase DNA binding protein 7
Database Link	NP_060250 Entrez Gene 320790 MouseEntrez Gene 55636 Human UniProt ID Q9P2D1
Background	CHD7 Antibody: CHD proteins belong to a superfamily of proteins of ATP-dependent chromatin remodeling enzymes that have a unique combination of functional domains, including two N-terminal chromodomains, a SNF2-like ATPase/helicase domain and a DNA-binding domain. These proteins are thought to play a role in early embryonic development by affecting chromatin structure and gene expression. Mutations in one member of this family, CHD7, result in CHARGE syndrome. It colocalizes with embryonic stem (ES) cell master regulators OCT4/POU5F1, SOX2, and NANOG and is thought to modulate ES-specific gene transcription. Together with SOX2, CHD7 has been suggested to also regulate several human disease genes.
Synonyms	CRG; HH5; IS3; KAL5
Reference Data

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