SCUBE2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL, ICC: 20 ug/mL, IF: 20 ug/mL
Reactivity	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SCUBE2 antibody was raised against a 17 amino acid synthetic peptide near the center of human SCUBE2.
Formulation	SCUBE2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	SCUBE2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	signal peptide, CUB domain and EGF like domain containing 2
Database Link	NP_066025 Entrez Gene 499241 RatEntrez Gene 57758 Human UniProt ID Q9NQ36
Background	SCUBE2 Antibody: SCUBE2 is a member of a family of secreted glycoproteins that contain N-terminal EGF-like repeats and C-terminal cysteine-rich motifs and CUB domain and are expressed in embryonic neuroectoderm and vascular epithelium. SCUBE2 is a close homolog to SCUBE1 and can form a heterodimeric complex with SCUBE1. SCUBE2 is thought to participate in the Hedgehog signaling pathway by specifically interacting with Sonic Hedgehog (SHH) and the receptor PTCH1, enhancing the SHH signaling activity in the raft microdomains of the plasma membrane, and may thus play important roles in organ development and tumor progression.
Synonyms	CEGB1; CEGF1; CEGP1
Reference Data
Protein Families	Transmembrane

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