KREMEN2 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 1 ug/mL
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KREMEN2 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KREMEN2 .
Formulation	KREMEN2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification	KREMEN2 Antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 51 kDa; Observed: 54 kDa
Gene Name	kringle containing transmembrane protein 2
Database Link	NP_757384 Entrez Gene 79412 Human UniProt ID Q8NCW0
Background	KREMEN2 Antibody: Kremen (Kringle containing protein marking the eye and the nose) proteins are type I transmembrane proteins that contain extracellular kringle, WSC and CUB domains and an intracellular region without any conserved motifs. Kremens bind a subset of the secreted Dickkopf proteins (Dkk 1, 2, and 4) with high affinity to modulate the canonical Wnt signaling pathway that is transduced by the ternary receptor complex composed of Wnt, Frizzled, and the LDL receptor related protein 5/6 (LRP5/6) co-receptor. Recent experiments have shown that KREMEN2 is a regulator of bone remodeling and raise the possibility that antagonizing KREMEN2 might prove beneficial in patients with bone loss disorders.
Synonyms	kringle-containing transmembrane protein 2; kringle containing transmembrane protein 2; KRM2; MGC10791; MGC16709
Reference Data

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